Intrahepatic Cholestasis of Pregnancy

A reversible form of cholestasis that typically occurs in the third trimester of pregnancy and frequently recurs in subsequent pregnancies. Patients present with PRURITIS; JAUNDICE increased serum bile salts, and abnormal liver enzyme levels. Symptoms resolve soon after delivery; some patients with may also be susceptible to oral contraceptive-induced cholestasis. Fetal complications may occur, including PLACENTAL INSUFFICIENCY; PREMATURE LABOR; FETAL DISTRESS, and intrauterine death . A heterozygous mutation in the ATP8B1 gene has been identified. OMIM: 147480

Also Known As:

Cholestasis, Intrahepatic, Of Pregnancy; Cholestasis, Pregnancy-Related; Cholestasis, intrahepatic of pregnancy; Familial intrahepatic cholestasis of pregnancy; Familial recurrent intrahepatic cholestasis of pregnancy; Obstetric Cholestasis; Pregnancy related cholestasis; Pregnancy-Related Cholestasis; Recurrent intrahepatic cholestasis of pregnancy

Digestive System Diseases: 1042
- Liver Diseases: 41660
  - Intrahepatic Cholestasis: 1064
    - Intrahepatic Cholestasis of Pregnancy: 730
- Biliary Tract Diseases: 466
  - Bile Duct Diseases: 95
    - Cholestasis: 7937
      - Intrahepatic Cholestasis: 1064
        Intrahepatic Cholestasis of Pregnancy: 730
Urogenital Diseases: 126
- Female Urogenital Diseases and Pregnancy Complications
  - Pregnancy Complications: 2961
    - Intrahepatic Cholestasis of Pregnancy: 730

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Disease

Drug/Important Bio-Agent (IBA)